Anti-Wrinkle Ingredients: Argireline

By: Senior LetsTalkBeauty Editor  |  Brittany Kline

General Overview

Argireline (Also known as Acetyl Hexapeptide 3 or Acetyl Hexapeptide 8) is a synthetic ingredient included in several anti-wrinkle cosmetic products. It is simply a shortened strand of Botulinum toxin, more commonly referred to as Botox. When applied topically, Argireline suppresses the body’s ability to release neurotransmitters (The chemicals that allow the cells in your body to communicate with each other) in the affected patch of skin, allowing your muscles to remain relaxed for extended periods of time. In doing so, Argireline greatly reduces your chances of developing wrinkles and expression lines. Due to this ability, Argireline is commonly found in cosmetic products that are designed with the intent of masking or suppressing signs of aging, including moisturizers, lotions, anti-aging treatments, eye creams, and concealers.

Side Effects & Potential Dangers

Argireline is an ingredient which has only been discovered recently, and very few studies have been published regarding the potential side effects that can result from interacting with it. The handful of studies that have been conducted so far have not revealed any immediate dangers as a result of exposure to Argireline, so cosmetic companies are currently including it in products as an alternative to Botulinum toxins. A potential danger that can result from exposure to Argireline, a danger which has yet to be clinically studied, is the possibility that it can induce sagging of facial muscles. By itself, Argireline indiscriminately affects any and all muscles that are exposed to it. When applied to face, however, Argireline has the potential to affect the firmness of facial muscles by suppressing neurotransmitters in those muscles, which can result in sagging facial muscles. Any consumer who is concerned with facial sagging should be careful when using products that contain Argireline until studies are published on the potential dangers that it may represent.

Clinical Research

Argireline has been subjected to clinical testing involving both living and inanimate organic test subjects, but it has not been subjected to any published double-blind trials (Rigorous scientific trials that are designed to exclude biased results from both the subjects and the researchers). Clinical studies of the effects of Argireline have been published by the Universidad Miguel Hernández (http://www.ncbi.nlm.nih.gov/pubmed/18498523) and the Universidad de Granada (http://www.ncbi.nlm.nih.gov/pubmed/17520155). These studies found that Argireline was not toxic when introduced orally, and did not cause significant irritation to the subjects at high doses. As a result, the studies concluded that Argireline is a biologically safe alternative to Botulinum toxins when used in cosmetic products.

For information about products that contain Argireline, see our anti-wrinkle cream comparison chart here, or our anti-wrinkle serum comparison chart here.

Brittany Kline
Senior LetsTalkBeauty Editor
We sent Brittany to venture across the world in search of discovering basically the world's best products and then bringing those back to you. She has documented all her research so you can receive the most vital information and latest innovations in beauty.
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